Effect of nonsymmetrical flow resistance upon orifice impedance resistance

A nonreactive orifice in an infinite baffle is analyzed. The pressure difference delta across the orifice varies sinusoidally with amplitude 1.0 and average value -P. The orifice resistance, delta p is discontinuous at zero velocity and exhibits the constant values R sub + and R sub - for u 0 and u 0, respectively. The resultant velocity has power in all harmonics of the excitation frequency. A quasi-linear resistance is defined and found to be relatively insensitive to the presence or absence of a resonant backing cavity; however, it does vary from 1.33 R sub + to 0.67 R sub + for a resistance ratio R sub +/R sub - between 0.5 and 2.0

Solubility of Sulfur Dioxide in Sulfuric Acid

The solubility of sulfur dioxide in 50% (wt./wt.) sulfuric acid was evaluated by regular solution theory, and the results verified by experimental measurements in the temperature range of 25 C to 70 C at pressures of 60 to 200 PSIA. The percent (wt./wt.) of sulfur dioxide in 50% (wt./wt.) sulfuric acid is given by the equation %SO2 = 2.2350 + 0.0903P - 0.00026P 10 to the 2nd power with P in PSIA

Transonic Navier-Stokes solutions of three-dimensional afterbody flows

The performance of a three-dimensional Navier-Stokes solution technique in predicting the transonic flow past a nonaxisymmetric nozzle was investigated. The investigation was conducted at free-stream Mach numbers ranging from 0.60 to 0.94 and an angle of attack of 0 degrees. The numerical solution procedure employs the three-dimensional, unsteady, Reynolds-averaged Navier-Stokes equations written in strong conservation form, a thin layer assumption, and the Baldwin-Lomax turbulence model. The equations are solved by using the finite-volume principle in conjunction with an approximately factored upwind-biased numerical algorithm. In the numerical procedure, the jet exhaust is represented by a solid sting. Wind-tunnel data with the jet exhaust simulated by high pressure air were also obtained to compare with the numerical calculations

Should we recommend universal neonatal hearing screening?

Universal neonatal hearing screening leads to both earlier detection and earlier treatment of infants with hearing loss (strength of recommendation [SOR]: A, based on a systematic review). Available evidence suggests early identification and intervention may improve language outcomes (SOR: C, based on retrospective cohort studies)

Human somatic mutation assays as biomarkers of carcinogenesis.

This paper describes four assays that detect somatic gene mutations in humans: the hypoxanthine-guanine phosphoribosyl transferase assay, the glycophorin A assay, the HLA-A assay, and the sickle cell hemoglobin assay. Somatic gene mutation can be considered a biomarker of carcinogenesis, and assays for somatic mutation may assist epidemiologists in studies that attempt to identify factors associated with increased risks of cancer. Practical aspects of the use of these assays are discussed

Switching roles: the functional plasticity of adult tissue stem cells.

Adult organisms have to adapt to survive, and the same is true for their tissues. Rates and types of cell production must be rapidly and reversibly adjusted to meet tissue demands in response to both local and systemic challenges. Recent work reveals how stem cell (SC) populations meet these requirements by switching between functional states tuned to homoeostasis or regeneration. This plasticity extends to differentiating cells, which are capable of reverting to SCs after injury. The concept of the niche, the micro-environment that sustains and regulates stem cells, is broadening, with a new appreciation of the role of physical factors and hormonal signals. Here, we review different functions of SCs, the cellular mechanisms that underlie them and the signals that bias the fate of SCs as they switch between roles.We thank J. Fowler, J. Frede, P. Greulich, A.M. Klein, K. Murai, B.D. Simons and D.J. Winton for discussions. We acknowledge the support of the Medical Research Council, the Wellcome Trust (Project grant WT090334MA, P.H.J. and PhD studentship Programme in Stem Cell Biology & Medicine, A.W.) and Cancer Research UK (Programme Grant C609/A17257, P.H.J.).This is the author accepted manuscript. The final version is available via EMBO at http://emboj.embopress.org/content/34/9/1164.long#ack-1

The Art of Clinical Supervision: Pastoral Counseling (New York and Mahwah, NJ: Paulist Press, 1987)

Reviewed by Peter Yuichi Clark

Literacy practices of primary education children in Andalusia (Spain): a family-based perspective

Primary school children develop literacy practices in various domains and situations in everyday life. This study focused on the analysis of literacy practices of children aged 8–12 years from the perspec- tive of their families. 1,843 families participated in the non-experimental explanatory study. The children in these families speak Spanish as a first language and are schooled in this language. The instrument used was a self-report questionnaire about children’s home-literacy practices. The data obtained were analysed using categorical principal components analysis (CATPCA) and analysis of variance (ANOVA). The results show the complex relationship between literacy practices developed by children in the domains of home and school and the limited development of a literacy-promoting ‘third space’. In conclusion, the families in our study had limited awareness of their role as literacy- promoting agents and thought of literacy learning as restricted to formal or academic spaces

Antibacterial Activity of and Resistance to Small Molecule Inhibitors of the ClpP Peptidase

There is rapidly mounting evidence that intracellular proteases in bacteria are compelling targets for antibacterial drugs. Multiple reports suggest that the human pathogen Mycobacterium tuberculosis and other actinobacteria may be particularly sensitive to small molecules that perturb the activities of self-compartmentalized peptidases, which catalyze intracellular protein turnover as components of ATP-dependent proteolytic machines. Here, we report chemical syntheses and evaluations of structurally diverse β-lactones, which have a privileged structure for selective, suicide inhibition of the self-compartmentalized ClpP peptidase. β-Lactones with certain substituents on the α- and β-carbons were found to be toxic to M. tuberculosis. Using an affinity-labeled analogue of a bioactive β-lactone in a series of chemical proteomic experiments, we selectively captured the ClpP1P2 peptidase from live cultures of two different actinobacteria that are related to M. tuberculosis. Importantly, we found that the growth inhibitory β-lactones also inactivate the M. tuberculosis ClpP1P2 peptidase in vitro via formation of a covalent adduct at the ClpP2 catalytic serine. Given the potent antibacterial activity of these compounds and their medicinal potential, we sought to identify innate mechanisms of resistance. Using a genome mining strategy, we identified a genetic determinant of β-lactone resistance in Streptomyces coelicolor, a non-pathogenic relative of M. tuberculosis. Collectively, these findings validate the potential of ClpP inhibition as a strategy in antibacterial drug development and define a mechanism by which bacteria could resist the toxic effects of ClpP inhibitors.National Institutes of Health (U.S.) (Grant GM-101988